GLP-1(S)
Compliance & Safety Protocol
FOR RESEARCH PURPOSES ONLY. NOT FOR HUMAN USE.
Research Profile
What is Semaglutide?
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910463-68-2), Semaglutide incorporates a C18 fatty di-acid side chain attached to lysine at position 26 and modified amino acid substitutions at positions 8 (Aib), 34 (Arg), and a truncated C-terminus.
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-eicosanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-GlySpecifications
| CAS Number | 910463-68-2 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.58 g/mol |
| Purity | ≥99.7% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | -20 °C, lyophilized |
| Shipping | Insulated packaging |
Mechanism of Action
GLP-1 Receptor
Gs-protein couplingSemaglutide binds to GLP-1 receptors with high affinity, activating Gs-proteins and increasing intracellular cAMP levels in beta-cell models.
Albumin Binding
Lipophilic side chain interactionThe C18 fatty di-acid side chain enables reversible albumin binding, extending circulation half-life in biochemical studies.
Receptor Internalization
Endocytosis/recyclingPublished studies indicate Semaglutide promotes receptor internalization with distinct kinetics compared to native GLP-1.
Storage & Handling
Related Compounds
Research Use Only
All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
Ancillary Compounds
Scientific Context
Related Research & Analysis
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